In a novel study from Queen’s University Belfast, researchers demonstrate that the eye could be a window to the brain. The results of the study, recently published in the Journal of Ophthalmic Research, show how degenerative brain diseases such as Alzheimer’s Disease (AD) can be monitored via ultra-widefield (UWF) retinal imaging. The retina is a part of the central nervous system and shares structural and functional features with the brain. Altogether 59 AD patients and 48 controls were entered into the study. They were imaged utilizing ultra-widefield imaging from Optos. This advanced technology, using red and green lasers, captures a 200 degree, high-resolution digital image of the retina in less than ½ second, reaching regions of the retina that have been previously inaccessible with other methods of imaging.
Measuring biomarkers, such as drusen and vasculature width gradients in delineated quadrants of the retina, the researchers found that these changes, particularly in the peripheral retina, could be associated with degenerative brain conditions such as AD. Specifically, the markers that were chiefly considered were drusen and vasculature changes. Drusen are deposits of fats, minerals, and proteins and are normal symptoms of aging that appear as yellowish spots in the layer beneath the …